Iodixanol

Iodixanol Properties

Melting point	262-267°C (dec.)
Boiling point	1250.9±65.0 °C(Predicted)
Density	1.266 ±0.003
vapor pressure	0Pa at 20℃
refractive index	n 1.4128 ±0.0003
storage temp.	Refrigerator
solubility	Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
form	liquid
pka	11.04±0.46(Predicted)
color	White
LogP	0.7
FDA UNII	HW8W27HTXX
NCI Drug Dictionary	iodixanol
ATC code	V08AB09
EPA Substance Registry System	1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
UNSPSC Code	41116107
NACRES	NA.75

SAFETY

Risk and Safety Statements

HS Code	2924296000
Hazardous Substances Data	92339-11-2(Hazardous Substances Data)
Toxicity	LD50 i.v. in mice: 21 gI/kg (Palmers)

Iodixanol price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001294	Iodixanol European Pharmacopoeia (EP) Reference Standard	92339-11-2	y0001294	$220	2024-03-01	Buy
Sigma-Aldrich	PHR3015	Iodixanol pharmaceutical secondary standard, certified reference material	92339-11-2	500MG	$230	2024-03-01	Buy
Sigma-Aldrich	1343517	Iodixanol	92339-11-2	200mg	$436	2024-03-01	Buy
TRC	I667200	Iodixanol	92339-11-2	100mg	$1165	2021-12-16	Buy
American Custom Chemicals Corporation	API0007294	IODIXANOL (60% SOLUTION IN WATER) 95.00%	92339-11-2	1G	$12400	2021-12-16	Buy

Product number	Packaging	Price	Buy
Y0001294	y0001294	$220	Buy
PHR3015	500MG	$230	Buy
1343517	200mg	$436	Buy
I667200	100mg	$1165	Buy
API0007294	1G	$12400	Buy

Iodixanol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

OptiPrep,Nycomed Pharma,Norway

Uses

Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).

Definition

ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Manufacturing Process

Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal (0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2 (42.5 ml) was added through a dropping funnel over 1 hour. The solution was heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g) was suspended in acetic anhydride (480 ml) and heated to 50°C. Concentrated sulfuric acid (3 ml) was then added. The starting material was dissolved after a few minutes, and the reaction mixture was heated at 60°C for 75 min. After cooling the residue dissolved in methanol (300 ml) with water (150 ml) the solution was heated to 50°C and the pH adjusted to about 10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and the hydrolysis was complete. The reaction mixture was cooled to 20°C and neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido- 2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophtalamide (304 g) was added after two hours of stirring. All solids were allowed to dissolve overnight before cooling to 30°C and adjustment to pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the solution after further cooling to 15°C, and the reaction was allowed to proceed for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was obtained.

brand name

Visipaque (GE Healthcare).

Therapeutic Function

Diagnostic aid

General Description

Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.

Iodixanol synthesis

Synthesis of Iodixanol from 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide and Epichlorohydrin

Iodixanol Preparation Products And Raw materials

Raw materials

1,3-Dichloro-2-propanol Sulfuric acid Dimethyl 5-nitroisophthalate Epichlorohydrin Sodium hydroxide

Hydrochloric acid 2-Methoxyethanol Acetic anhydride

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Preparation Products

Iodixanol Suppliers

Global( 277)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	lvan.hui@jsytsw.com	China	80	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12798	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5868	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	295	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	485	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1001	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29857	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58

Supplier	Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hangzhou Hyper Chemicals Limited	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanxi Naipu Import and Export Co.,Ltd	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58

View Lastest Price from Iodixanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-30	Iodixanol 92339-11-2			0.99		RongNa Biotechnology Co.,Ltd
2025-04-30	Iodixanol 92339-11-2	US $0.00-0.00 / kg	1kg	98	1000	Wuhan Circle Star Chem-medical Technology Co.,Ltd
2025-04-30	Iodixanol 92339-11-2	US $0.00 / Kg/Bag	1KG	98.6%~101.0%; USP37	2000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD

Iodixanol
92339-11-2
0.99
RongNa Biotechnology Co.,Ltd

Iodixanol
92339-11-2
US $0.00-0.00 / kg
98
Wuhan Circle Star Chem-medical Technology Co.,Ltd

Iodixanol
92339-11-2
US $0.00 / Kg/Bag
98.6%~101.0%; USP37
WUHAN FORTUNA CHEMICAL CO., LTD

92339-11-2(Iodixanol)Related Search:

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Epichlorohydrin 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide 5-Amino-N,N'-bis(2,3-dihydroxypropyl)isophthalamide 1,3-BIS(DIMETHYLAMINO)-2-PROPANOL 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

Haloperidol Iohexol 5-AMINO-ISOPHTHALAMIDE

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Acupaque DU-6807 Iodixanol (200 mg) 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetyliMino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- odixanol IODIXANOL 1,3-benzenedicarboxamide,5,5’-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis n’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-( 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- 2-5410-3A 5,5'-((2-Hydroxy-1,3-propanediyl)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide 5,5'-[(2-Hydroxytrimethylene)bis(acetylimino)]bis[N,N/1-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide 5-[acetyl-[3-[N-acetyl-3,5-bis[(2,3-dihydroxypropylamino)-oxomethyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide iodexanol 5-[acetyl-[3-[N-acetyl-3,5-bis[[(2S)-2,3-dihydroxypropyl]carbamoyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis[(2S)-2,3-dihydroxypropyl]-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol CRS 5,5'-((2-hydroxypropane-1,3-diyl)bis(acetylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) Iodixanol USP/EP/BP lodoanol Iodixanol (Visipaque, Iodixanolum, OptiPrep) IodixanolQ: What is Iodixanol Q: What is the CAS Number of Iodixanol Q: What is the storage condition of Iodixanol Q: What are the applications of Iodixanol Iodixanol (1343517) OptiPrep Visipaque Ioxanol Ioxaxol 5,5'-((2-Hydroxypropane-1,3-diyl)bis(acetylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) , Iodixanol C14330000 Iodixanol 5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol, 10 mM in DMSO Iothalamate OptiPrep^? Density Gradient Medium 92339-11-2 922339-11-2 16253-78-3 C35H44I6N6O15 Aromatics Diagnostic Intermediates & Fine Chemicals Pharmaceuticals 92339-11-2