Irgarol synthesis
- Product Name:Irgarol
- CAS Number:28159-98-0
- Molecular formula:C11H19N5S
- Molecular Weight:253.37
Yield:28159-98-0 93%
Reaction Conditions:
with potassium tert-butylate;palladium diacetate;triphenylphosphine;potassium thioacetate in dimethyl sulfoxide at 120;Inert atmosphere;
Steps:
50 Example 50
Under a nitrogen atmosphere,The substrate triazine compound 4h (0.2 mmol, 48.2 mg) was added to a 25 mL test tube reactor, KSAc(0.6mmol,68.4mg),DMC(1.0mmol,90mg),Pd(OAc)2(0.01mmol,2.3mg),PPh3 (0.02mmol,5.9mg),tBuOK(0.6mmol,69.2mg),and DMSO(2.0mL). The reaction was heated to 120 ° C to carry out the reaction.After the TLC detection reaction was completed,The system was cooled to room temperature.The reaction was quenched with saturated aqueous ammonium chloride,And extracted with ethyl acetate (3 * 10 mL)Column chromatography gave the product 5h 47.1 mg (93%).
References:
East China Normal University;Jiang Xuefeng;Qiao Zongjun CN106866327, 2017, A Location in patent:Paragraph 0188; 0189; 0190
