Terbutryn synthesis

Yield:886-50-0 99%

Reaction Conditions:

with potassium tert-butylate;palladium diacetate;triphenylphosphine;potassium thioacetate in dimethyl sulfoxide at 120;Inert atmosphere;

Steps:

49 Example 49
Under a nitrogen atmosphere,A 4 mL (0.2 mmol, 40.2 mg) solution of cimetidine was added to a 25 mL test tube reactor, KSAc(0.6mmol,68.4mg),DMC(1.0mmol,90mg),Pd(OAc)2(0.01mmol,2.3mg),PPh3(0.02mmol,5.9mg),tBuOK(0.6mmol,69.2mg),and DMSO(2.0mL).The reaction was heated to 120 ° C to carry out the reaction.After the TLC detection reaction was completed,The system was cooled to room temperature.The reaction was quenched with saturated aqueous ammonium chloride,And extracted with ethyl acetate (3 * 10 mL)Column chromatography gave 5 g of product (47.7 mg, 99%).

References:

East China Normal University;Jiang Xuefeng;Qiao Zongjun CN106866327, 2017, A Location in patent:Paragraph 0185; 0186; 0187

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