![](/CAS/GIF/263888-58-0.gif)
ISOINDOLINE-5-CARBONITRILE synthesis
- Product Name:ISOINDOLINE-5-CARBONITRILE
- CAS Number:263888-58-0
- Molecular formula:C9H8N2
- Molecular Weight:144.17
![TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE](/CAS/GIF/263888-56-8.gif)
263888-56-8
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![ISOINDOLINE-5-CARBONITRILE](/CAS/GIF/263888-58-0.gif)
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Yield: 99.9%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 15; for 2 h;
Steps:
26 Isoindoline-5-carbonitrile
The solution of tert-butyl 5-cyanoisoindoline-2-carboxylate (4.00 g, 16.4 mmol) in TFA/DCM (2M, 100 nil) was stirring at 15 °C lbr 120 miii. After LC-MS showed the reaction was completed, the reaction solution was concentrated to give the title compound (2.36 g, 99.9 %), which was used for the next step directly.
References:
KADMON CORPORATION, LLC;KIM, Ji-in;LIU, Kevin;POYUROVSKY, Masha;LU, Dan;ZHU, Zhenping WO2015/54317, 2015, A1 Location in patent:Paragraph 0276; 0277
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![ISOINDOLINE-5-CARBONITRILE](/CAS/GIF/263888-58-0.gif)
263888-58-0
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54544-67-1
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![ISOINDOLINE-5-CARBONITRILE](/CAS/GIF/263888-58-0.gif)
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![ISOINDOLINE-5-CARBONITRILE](/CAS/GIF/263888-58-0.gif)
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![ISOINDOLINE-5-CARBONITRILE](/CAS/GIF/263888-58-0.gif)
263888-58-0
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