Isopropyl 4-aminopiperidine-1-carboxylate synthesis
- Product Name:Isopropyl 4-aminopiperidine-1-carboxylate
- CAS Number:502931-34-2
- Molecular formula:C9H18N2O2
- Molecular Weight:186.25
902143-82-2
1 suppliers
inquiry
502931-34-2
13 suppliers
inquiry
Yield:502931-34-2 89%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 2 h;
Steps:
18.B
To a solution of 18a (3.26 g, 11.37 mmol) in 10 mL of DCM, was added TFA (5 mL, 64.9 mmol). The mixture was stirred at room temperature for 2h and the solvent were evaporated. The residue was dissolved in DCM and a saturated solution of NaHCOs and IN NaOH were added until pH was 8. The layers were separated and the aqueous layer was extracted with 3:1 DCM:IPA (3 x 40 mL). The organic extracts were combined, dried, filtered and evaporated to afford 1.89 g (89%) of 18b.
References:
WO2010/149685,2010,A1 Location in patent:Page/Page column 50
73874-95-0
447 suppliers
$10.00/250mg
502931-34-2
13 suppliers
inquiry