ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:80370-40-7
- Molecular formula:C6H7NO3
- Molecular Weight:141.12
503471-30-5
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Yield: 81%
Reaction Conditions:
with hydroxylamine hydrochloride in ethanol for 2 h;Heating / reflux;
Steps:
21e
Experiment 21; The intermediate 2, was prepared in 37% yield using the method as described in ref.: J. Org. Chem. 1982, 47, 2216-17. The ethyl ester 4 was prepared by the literature method (Ref: Gazz. CMm. Ital. 1947, 77, 206-12). Following lithium aluminium hydride reduction gave the alcohol 5 which was oxides to the aldehyde 6.
References:
AVEXA LIMITED WO2007/124546, 2007, A1 Location in patent:Page/Page column 61
80370-42-9
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80370-40-7
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68776-58-9
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80370-40-7
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