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138716-36-6

Isoxazole, 5-(2-fluorophenyl)- (9CI) synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: NaH / tetrahydrofuran / 2.5 h / 20 °C
2: NH2OH*HCl / tetrahydrofuran; H2O / 17 h / 20 °C

References:

Swain, Christopher J.;Teran, Ana;Maroto, Marta;Cabello, Angeles [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 23,p. 6058 - 6062]