JNJ 1661010 synthesis
- Product Name:JNJ 1661010
- CAS Number:681136-29-8
- Molecular formula:C19H19N5OS
- Molecular Weight:365.45
306935-14-8
40 suppliers
$108.75/500mg
103-71-9
3 suppliers
$20.19/5g
681136-29-8
79 suppliers
$59.00/5mg
Yield: 80.4%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 0 - 20; for 3 h;
Steps:
25
Example 25; N-Phenyl-4-(3-phenyl-l,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; To a solution of 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine (1.00 g, 4.06 mmol) and triethylamine (0.565 ml, 4.06 mmol) in tetrahydrofuran (20 ml) was added, under ice-cooling, phenyl isocyanate (0.529 ml, 4.87 mmol), and the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added diisopropyl ether (40 ml), and the solid was separated by filtration. The resulting solid was recrystallized from a mixed solvent of hexane and ethyl acetate to give 1.19 g (80.4%) of the desired product as a solid. 1H-NMR (CDCl3) δ; 3.70 (8H, s), 6.43 (1H, s), 7.06 - 7.11 (1H, m), 7.29 - 7.46 (7H, m), 8.17 - 8.21 (2H, m).
References:
Takeda Pharmaceutical Company Limited EP1813606, 2007, A1 Location in patent:Page/Page column 32-33
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
