Ketone Ester synthesis
- Product Name:Ketone Ester
- CAS Number:1208313-97-6
- Molecular formula:C8H16O4
- Molecular Weight:176.21
75351-36-9
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13613-65-5
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1208313-97-6
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Yield:1208313-97-6 92%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide;sodium hydroxide in acetonitrile at 75 - 80;Reagent/catalyst;Temperature;Solvent;
Steps:
1; 2
(R)-3-Hydroxybutyl-4-methylbenzenesulfonate (100.0 g, 0.41 mol) was diluted in toluene (1L) was added. Sodium (R)-3-hydroxybutyrate (51.6g, 0.41mol) at room temperature. Raise the temperature to 80-90 °C and react for 20-24 hours. TLC monitors the completion of the reaction. The reaction solution was cooled to room temperature and filtered with suction. The filtrate was concentrated to dryness under reduced pressure. Add methyl tert-butyl ether (500 mL) to the residue, stir and filter with suction. The filtrate was concentrated to dryness under reduced pressure to obtain (R)-3-hydroxybutyryl-(R)-3-hydroxybutyl ester (65 g, yield: 90.0%, purity: 95%).
References:
CN113045416,2021,A Location in patent:Paragraph 0044-0048; 0049; 0052; 0053; 0055
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24915-95-5
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1208313-97-6
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625-72-9
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