L-GLUTAMIC-2,3,3,4,4-D5 ACID synthesis
- Product Name:L-GLUTAMIC-2,3,3,4,4-D5 ACID
- CAS Number:2784-50-1
- Molecular formula:C5H4D5NO4
- Molecular Weight:152.16
1381759-60-9
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2784-50-1
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$382.00/2.5mg
Yield: 99%
Reaction Conditions:
with α-D-glucopyranose-1-d1;NAD;ammonium chloride in water-d2; pH=7 at 20;Enzymatic reaction;
Steps:
4 Preparation of Deuterated Glutamic acid 20
Scheme 4 depicts a preparation of deuterated glutamic acid 20. Succinic acid 23 was treated with DC1 in D20 to provide, after quenching with a mineral acid such as HC1, 24, which was treated with D-glucose-Di NAD (Nicotinamide adenine dinucleotide). D-glucose- Di is the following compound (shown below in its open chain and pyranose forms):
References:
CONCERT PHARMACEUTICALS, INC.;TUNG, Roger, D. WO2014/110322, 2014, A2 Location in patent:Paragraph 91; 92
328-50-7
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2784-50-1
46 suppliers
$382.00/2.5mg