![](/CAS/20180906/GIF/102767-28-2.gif)
Levetiracetam synthesis
- Product Name:Levetiracetam
- CAS Number:102767-28-2
- Molecular formula:C8H14N2O2
- Molecular Weight:170.209
![(S)2-(2-Oxo pyrrolidin-1-yl)-Butiric acid methyl ester](/CAS/20200401/GIF/358629-51-3.gif)
358629-51-3
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![Levetiracetam](/CAS/20180906/GIF/102767-28-2.gif)
102767-28-2
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Yield:102767-28-2 97.5%
Reaction Conditions:
with ammonium hydroxide at -5 - 0; for 8 h;
Steps:
1.D; 2.D; 3.D; 4.D D: Ammonolysis reaction
add ammonium hydroxide 60.81kg in the reactor, be cooled to -5degC , drip (S)-2-(2-oxopyrrolidin-1-yl) methyl butyrate 13.79kg, After dripping, the reaction was incubated at -50°C for 8 hours, the water was evaporated under reduced pressure, 62.5 kg of ethyl acetate was added to make pulp, centrifuged, and dried under reduced pressure to obtain 12.36 kg of the final product levetiracetam, with a molar yield of 97.5%. Starting from the starting material (S)-2-aminobutyric acid to the final product levetiracetam, the total molar yield was 48.28%, the HPLC purity was 99.90%, and the optical purity was 99.91%.
References:
CN114409586,2022,A Location in patent:Paragraph 0038; 0042-0043; 0047-0048; 0052-0053; 0057
![(2S)-2-(2-Oxopyrrolidin-1-yl)butanoic acid](/CAS/GIF/102849-49-0.gif)
102849-49-0
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![Levetiracetam](/CAS/20180906/GIF/102767-28-2.gif)
102767-28-2
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$5.00/1g
![(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt](/CAS/GIF/102916-46-1.gif)
102916-46-1
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![Levetiracetam](/CAS/20180906/GIF/102767-28-2.gif)
102767-28-2
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![Methyl 4-chlorobutyrate](/CAS/GIF/3153-37-5.gif)
3153-37-5
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![2-Aminobutanamide](/CAS/GIF/53726-14-0.gif)
53726-14-0
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![Levetiracetam](/CAS/20180906/GIF/102767-28-2.gif)
102767-28-2
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![ETHYL 4-CHLOROBUTYRATE](/CAS/GIF/3153-36-4.gif)
3153-36-4
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$14.00/25mL
![2-Aminobutanamide](/CAS/GIF/53726-14-0.gif)
53726-14-0
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![Levetiracetam](/CAS/20180906/GIF/102767-28-2.gif)
102767-28-2
735 suppliers
$5.00/1g