ChemicalBook CAS DataBase List Lipoic acid

Lipoic acid synthesis

9synthesis methods

Product Name:Lipoic acid
CAS Number:62-46-4
Molecular formula:C8H14O2S2
Molecular Weight:206.33

462-20-4 Synthesis

462-20-4
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62-46-4
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Yield:62-46-4 94%

Reaction Conditions:

with iron(III) chloride;sodium hydroxide in water at 35; for 12 h;Reagent/catalyst;Solvent;Temperature;

Steps:

1.I; 2.I; 3.I I) Preparation of finished product is to prepare α-lipoic acid:

In a 2L reaction flask, add Intermediate-8 (15.0g, 72.0mmol), FeCl3 (6.0g, 37.0mmol), NaOH (3.5g, 87.5mmol) and water (600mL), pass oxygen under stirring, and keep the temperature for 35 react for 12h, cool to room temperature, remove the organic solvent by rotary evaporation under reduced pressure at 50 , cool to 10 in an ice bath, add concentrated hydrochloric acid dropwise to pH=1, suction filtration, and vacuum dry to obtain α-lipoic acid (14.0g), Yield 94%, the reaction formula of the present embodiment is as follows

References:

CN113754630,2021,A Location in patent:Paragraph 0020; 0021