LUMEFANTRINE synthesis
- Product Name:LUMEFANTRINE
- CAS Number:204133-10-8
- Molecular formula:C30H32Cl3NO
- Molecular Weight:528.9402
![2,7-Dichloro-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol](/CAS2/GIF/69759-61-1.gif)
Yield:204133-10-8 246 kg
Reaction Conditions:
with sodium hydroxide in ethanol at 30 - 40; for 24 h;Large scale;
Steps:
1
Put intermediate into the reaction kettle R501, pump 2500L of absolute ethanol,Put in 20kg of sodium hydroxide and 118kg of p-chlorobenzaldehyde,Control the temperature of the reaction solution at 30-40 ° C and react for 24 hours,TLC detects the end of the reaction and ends the reaction to the point where there is no raw material.Cool down to 10-20 , centrifuge and spin to filter out wet powder.The wet powder is sent to the double cone dryer to dry 276kg of crude fluorene alcohol.2760L of acetone was pumped into the reaction kettle R601, and 276kg of crude fluorene alcohol was added.Heat and reflux for 1-2 hours to fully dissolve. Hot filtration to remove insoluble impurities,Reduce the temperature to 0-5 at a rate of 10 / h, precipitate yellow crystals, centrifuge and spin filter,The filter cake was washed with a small amount of acetone.The wet powder is sent to the yellow crystalline powdery solid dried in the double cone dryer,The weight is 246kg. After testing, the product meets quality standards.
References:
CN111039804,2020,A Location in patent:Paragraph 0041-0050; 0057-0058
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