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Melphalan EP impurity H synthesis

1synthesis methods
-

Yield:88457-23-2 93%

Reaction Conditions:

with thionyl chloride for 12 h;Reflux;

References:

Xu, Shengtao;Pei, Lingling;Wang, Chengqian;Zhang, Yun-Kai;Li, Dahong;Yao, Hequan;Wu, Xiaoming;Chen, Zhe-Sheng;Sun, Yijun;Xu, Jinyi [ACS Medicinal Chemistry Letters,2014,vol. 5,# 7,p. 797 - 802]