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Methyl 2-(3-methoxyphenyl)-2-oxoacetate synthesis

14synthesis methods
-

Yield:83585-22-2 74%

Reaction Conditions:

(3-methoxyphenyl)magnesium bromide;oxalic acid diethyl ester
Stage #2: with potassium hydroxide in methanol;
Stage #3: methyl iodidewith 1,8-diazabicyclo[5.4.0]undec-7-ene

References:

Fennie, Michael W.;DiMauro, Erin F.;O'Brien, Erin M.;Annamalai, Venkatachalam;Kozlowski, Marisa C. [Tetrahedron,2005,vol. 61,# 26,p. 6249 - 6265]