methyl 2-(4-aminophenyl)propionate synthesis

8synthesis methods

Product Name:methyl 2-(4-aminophenyl)propionate
CAS Number:39718-97-3
Molecular formula:C10H13NO2
Molecular Weight:179.22

50415-69-5 Synthesis

50415-69-5
37 suppliers
$74.03/0.5g

39718-97-3
33 suppliers
$45.00/10mg

Yield:39718-97-3 100%

Reaction Conditions:

with palladium 10% on activated carbon;ammonium formate at 20;

Steps:

25 4.1.25
(+-)-Methyl 2-(4-aminophenyl)propanoate (25e)

;To a solution of 24e (1.05 g, 5 mmol) in MeOH (20 mL) was added 10% Pd/C (0.37 g, 0.35 mmol) followed by the addition of HCO₂NH₄ (1.9 g, 30 mmol).
The solution was stirred at rt for 1 h.
The solution was filtered through a pad of Celite and the filtrate was concentrated under reduced pressure.
The residue was dissolved in EtOAc and filtered through a pad of SiO₂ to afford 25e as an off-white solid (0.89 g, quant.).

References:

Migliore, Marco;Habrant, Damien;Sasso, Oscar;Albani, Clara;Bertozzi, Sine Mandrup;Armirotti, Andrea;Piomelli, Daniele;Scarpelli, Rita [European Journal of Medicinal Chemistry,2016,vol. 109,p. 216 - 237]