methyl 2-(4-hydroxy-2-methylphenyl)acetate synthesis

6synthesis methods

Product Name:methyl 2-(4-hydroxy-2-methylphenyl)acetate
CAS Number:114474-04-3
Molecular formula:C10H12O3
Molecular Weight:180.2

30888-94-9
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methyl 2-(4-hydroxy-2-methylphenyl)acetate

114474-04-3
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Yield:114474-04-3 100%

Reaction Conditions:

with aluminum (III) chloride;ethanethiol in dichloromethane at 0 - 20; for 2 h;

Steps:

12(B) Step B

(4-Methoxy-2-methyl-phenyl) -acetic acid methyl ester (1.5 g, 7.72 mmol) is stirred in dichloromethane (50 mL) at 0 deg. C. Aluminum chloride (4.13 g, 31 mmol) is added followed by ethane thiol (2.9 mL, 38.6 MMOL). The resulting mixture is stirred at room temperature for 2 hr. Water (50 mL) is added and the product is extracted into ethyl acetate (3 X 50 ml), the extracts are combined, dried over anhydrous magnesium sulfate, filtered, and concentrated to afford the title compound as a colorless oil, 1.4 g, 100%. MS M+1 181. The structure is confirmed by 1H NMR spectroscopy.

References:

WO2004/63155,2004,A1 Location in patent:Page 57-58

223406-97-1 Synthesis