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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Methyl 2-(Boc-amino)isonicotinate
639091-75-1

Methyl 2-(Boc-amino)isonicotinate synthesis

5synthesis methods
A 500 mL round bottomed flask was charged with methyl 2-aminoisonicotinate (5.0 g, 32.9 mmol) and suspended in t-BuOH (200 mL). To this stirring solution was added di-tert-butyl dicarbonate (7.53 g, 34.5 mmol). The flask was vented and placed in an oil bath preheated to 50°C. The reaction mixture was let stir overnight. After 22 hours LCMS showed near complete conversion of starting material. The mixture was cooled to room temperature and filtered. The material was taken on without any further purification. Yield 5.93 g of white solid, Methyl 2-(Boc-amino)isonicotinate.  1H NMR (400 MHz, DMSO-d6) δ ppm 10.14 (1H, s), 8.43 (1H, dd, J=5.02, 0.75 Hz), 8.33 (1H, s), 7.45 (1H, dd, J=5.02, 1.51 Hz), 3.89 (3H, s), 1.48 (9H, s).
synthesis of Methyl 2-(Boc-amino)isonicotinate
6937-03-7 Synthesis
Methyl 2-aminopyridine-4-carboxylate

6937-03-7
215 suppliers
$8.00/1g

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
859 suppliers
$13.50/25G

Methyl 2-(Boc-amino)isonicotinate

639091-75-1
73 suppliers
$17.00/100mg

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Yield:639091-75-1 97%

Reaction Conditions:

with dmap in acetone;tert-butyl alcohol at 20; for 15 h;

References:

Poon, Jia-Fei;Alao, John Patrick;Sunnerhagen, Per;Dinér, Peter [Organic and Biomolecular Chemistry,2013,vol. 11,# 27,p. 4526 - 4536]

67-56-1 Synthesis
Methanol

67-56-1
773 suppliers
$9.00/25ml

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
859 suppliers
$13.50/25G

2-Aminoisonicotinic acid

13362-28-2
318 suppliers
$6.00/1g

Methyl 2-(Boc-amino)isonicotinate

639091-75-1
73 suppliers
$17.00/100mg

References
6313-54-8 Synthesis
2-Chloro-4-pyridinecarboxylic acid

6313-54-8
429 suppliers
$8.00/5g

Methyl 2-(Boc-amino)isonicotinate

639091-75-1
73 suppliers
$17.00/100mg

References
2-Aminoisonicotinic acid

13362-28-2
318 suppliers
$6.00/1g

Methyl 2-(Boc-amino)isonicotinate

639091-75-1
73 suppliers
$17.00/100mg

References
36016-38-3 Synthesis
tert-Butyl N-hydroxycarbamate

36016-38-3
365 suppliers
$6.00/5g

Methyl 2-(Boc-amino)isonicotinate

639091-75-1
73 suppliers
$17.00/100mg

References