METHYL 2-BROMO-1-ETHYL-1H-IMIDAZOLE-5-CARBOXYLATE synthesis

2synthesis methods

Product Name:METHYL 2-BROMO-1-ETHYL-1H-IMIDAZOLE-5-CARBOXYLATE
CAS Number:1398414-98-6
Molecular formula:C7H9BrN2O2
Molecular Weight:233.06

methyl 1-ethyl-1H-imidazole-5-carboxylate

71925-10-5
14 suppliers
inquiry

METHYL 2-BROMO-1-ETHYL-1H-IMIDAZOLE-5-CARBOXYLATE

1398414-98-6
8 suppliers
inquiry

Yield:-

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane at 50; for 4 h;

Steps:

33

The preceeding ester (265 mg, 1.7 mmol) NBS (612 mg, 3.4 mmol), and AIBN (15 mg, 0.1 mmol) are combined in CC1₄ (30 mL), and then heated to 50 °C for 4 h. The reaction is filtered hot through a short pad of diatomaceous earth, rinsing with additional CC1₄, then concentrated in vacuo to afford crude bromide 33-115 (450 mg).

References:

WO2012/122340,2012,A1 Location in patent:Page/Page column 87

17325-26-7 Synthesis

17325-26-7
224 suppliers
$13.00/250mg

1398414-98-6
8 suppliers
inquiry

References