ChemicalBook CAS DataBase List Methyl 4-imidazolecarboxylate

Methyl 4-imidazolecarboxylate synthesis

5synthesis methods

Product Name:Methyl 4-imidazolecarboxylate
CAS Number:17325-26-7
Molecular formula:C5H6N2O2
Molecular Weight:126.11

67-56-1 Synthesis

67-56-1
737 suppliers
$7.29/5ml-f

1072-84-0 Synthesis

1072-84-0
375 suppliers
$10.00/1g

17325-26-7
226 suppliers
$13.00/250mg

Yield:17325-26-7 99%

Reaction Conditions:

with thionyl chloride at 70; for 16 h;

Steps:

1 Step 1-Methyl 1H-imidazole-4-carboxylate
To a mixture of 1H-imidazole-4-carboxylic acid (5.00 g, 44.6 mmol, CAS1072-84-0) in MeOH (50 mL) was added SOCl₂(10.6 g, 89.2 mmol, 6.47 mL). The reaction mixture was stirred at 70° C. for 16 hours. On completion, the reaction mixture was concentrated in vacuo to give the title compound (5.60 g, 99% yield) as white solid. The residue was used to the next step directly without further purification. ¹H NMR (400 MHz, DMSO-d₆) δ 9.29-9.25 (m, 1H), 8.37 (s, 1H), 3.87 (s, 3H).

References:

Kymera Therapeutics, Inc.;Mainolfi, Nello;Ji, Nan;Kluge, Arthur F.;Weiss, Matthew M.;Zhang, Yi US2019/192668, 2019, A1 Location in patent:Paragraph 2699; 2700

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67-56-1 Synthesis

67-56-1
737 suppliers
$7.29/5ml-f

3034-50-2 Synthesis