Methyl 2-bromo-5-fluoro-4-methylbenzoate synthesis

Yield:1204304-98-2 50%

Reaction Conditions:

Stage #1: 5-amino-2-bromo-4-methylbenzoic acid methyl esterwith tetrafluoroboric acid;isopentyl nitrite in ethanol at -10;Balz-Schiemann reaction;
Stage #2: in 5,5-dimethyl-1,3-cyclohexadiene;ethanol;Reflux;

References:

Lv, Binhua;Xu, Baihua;Feng, Yan;Peng, Kun;Xu, Ge;Du, Jiyan;Zhang, Lili;Zhang, Wenbin;Zhang, Ting;Zhu, Liangcheng;Ding, Haifeng;Sheng, Zelin;Welihinda, Ajith;Seed, Brian;Chen, Yuanwei [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 24,p. 6877 - 6881] Location in patent:scheme or table