METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE synthesis
- Product Name:METHYL 2-BROMOMETHYL-4-FLUORO-BENZOATE
- CAS Number:157652-28-3
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
174403-69-1
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157652-28-3
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$21.00/100mg
Yield: 94%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane
Steps:
146 Preparation of 2-carbomethoxy-5-fluorobenzyl bromide STR222
Example 146 Preparation of 2-carbomethoxy-5-fluorobenzyl bromide STR222 A suspension of the compound of Example 145 (5.1 g, 30 mmol), N-bromosuccinimide (5.4 g, 30 mmol) and benzoyl peroxide (0.073 g, 0.30 mmol) in carbon tetrachloride (115 mL) was refluxed for 18 h. The reaction mixture was cooled to 0° C., filtered, and the precipitate was washed with diethyl ether. The solvent was removed in vacuo to afford 7.02 g (94% crude yield) of the title compound, contaminated with a small amount of succinimide. Rf =0.48 20% ethyl acetate/hexanes.
References:
Corvas International, Inc. US6011158, 2000, A
21900-43-6
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157652-28-3
78 suppliers
$21.00/100mg
321-21-1
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$6.00/1g
157652-28-3
78 suppliers
$21.00/100mg