Methyl 2-ethylbenzo[d]oxazole-5-carboxylate synthesis
- Product Name:Methyl 2-ethylbenzo[d]oxazole-5-carboxylate
- CAS Number:924862-20-4
- Molecular formula:C11H11NO3
- Molecular Weight:205.21
536-25-4
188 suppliers
$11.00/250mg
115-80-0
235 suppliers
$17.00/25mL
924862-20-4
15 suppliers
inquiry
Yield:924862-20-4 3.8 g
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 25; for 1.5 h;Inert atmosphere;
Steps:
465 2-ethyl-1,3-benzoxazole-5-carboxylate
2-ethyl-1,3-benzoxazole-5-carboxylate
Into a 100-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed methyl 3-amino-4-hydroxybenzoate (3 g, 17.95 mmol, 1.00 equiv), 1,1,1-triethoxypropane (37 mL), trifluoroacetic acid (2.2 mL). The resulting solution was stirred for 1.5 h at 25° C. The reaction solution was diluted with 50 mL of DCM. The mixture was washed with 2×20 mL of saturated aqueous NaHCO3 and 1×50 mL of brine. Then it was dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 3.8 g of methyl 2-ethyl-1,3-benzoxazole-5-carboxylate as a red brown oil.
References:
US2015/315198,2015,A1 Location in patent:Paragraph 1176; 1177
802294-64-0
1 suppliers
inquiry
536-25-4
188 suppliers
$11.00/250mg
924862-20-4
15 suppliers
inquiry