![](/CAS/GIF/536-25-4.gif)
Methyl 3-amino-4-hydroxybenzoate synthesis
- Product Name:Methyl 3-amino-4-hydroxybenzoate
- CAS Number:536-25-4
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
![3-Amino-4-hydroxybenzoic acid](/CAS/GIF/1571-72-8.gif)
1571-72-8
256 suppliers
$8.00/1g
![Methyl 3-amino-4-hydroxybenzoate](/CAS/GIF/536-25-4.gif)
536-25-4
189 suppliers
$11.00/250mg
Yield:536-25-4 100%
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
Step1: preparation of methyl 4-amino-3-nitrobenzoate (12).
General procedure: Toa solution of 4-amino-3-nitrobenzoic acid (11, 500 mg, 2.75 mmol) inMeOH (20 mL), a catalytic amount of concentrated sulfuric acid was added in a dropwisefashion. The mixture was heated at reflux temperature overnight. After beingcooled, the reaction was quenched by saturated NaHCO3solution andextracted by ethyl acetate.The organic layer was separated and dried over anhydroussodium sulfate. Filtration and concentrationin vacuogave 12 (519 mg, 97%); yellow solid
References:
Jaikhan, Pattaporn;Buranrat, Benjaporn;Itoh, Yukihiro;Chotitumnavee, Jiranan;Kurohara, Takashi;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 10,p. 1173 - 1176] Location in patent:supporting information
![Methyl 3-nitro-4-hydroxybenzoate](/CAS/GIF/99-42-3.gif)
99-42-3
184 suppliers
$8.00/5g
![Methyl 3-amino-4-hydroxybenzoate](/CAS/GIF/536-25-4.gif)
536-25-4
189 suppliers
$11.00/250mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
![4-Hydroxy-3-nitrobenzoic acid](/CAS/GIF/616-82-0.gif)
616-82-0
227 suppliers
$10.00/5g
![Methyl 3-amino-4-hydroxybenzoate](/CAS/GIF/536-25-4.gif)
536-25-4
189 suppliers
$11.00/250mg
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
562 suppliers
$17.92/100G
![3-Amino-4-hydroxybenzoic acid](/CAS/GIF/1571-72-8.gif)
1571-72-8
256 suppliers
$8.00/1g
![Methyl 3-amino-4-hydroxybenzoate](/CAS/GIF/536-25-4.gif)
536-25-4
189 suppliers
$11.00/250mg
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
208 suppliers
$33.00/5g
![3-Amino-4-hydroxybenzoic acid](/CAS/GIF/1571-72-8.gif)
1571-72-8
256 suppliers
$8.00/1g
![Methyl 3-amino-4-hydroxybenzoate](/CAS/GIF/536-25-4.gif)
536-25-4
189 suppliers
$11.00/250mg