![](/CAS/GIF/946126-94-9.gif)
methyl 2-fluoro-3-nitrobenzoate synthesis
- Product Name:methyl 2-fluoro-3-nitrobenzoate
- CAS Number:946126-94-9
- Molecular formula:C8H6FNO4
- Molecular Weight:199.14
![2.jpg 2.jpg](/NewsImg/2022-01-21/6377837018241861867985125.jpg)
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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![2-Fluoro-3-nitrobenzoic acid](/CAS/GIF/317-46-4.gif)
317-46-4
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$6.00/1g
![methyl 2-fluoro-3-nitrobenzoate](/CAS/GIF/946126-94-9.gif)
946126-94-9
157 suppliers
$28.00/1g
Yield:946126-94-9 99%
Reaction Conditions:
Stage #1: 2-fluoro-3-nitro-benzoic acidwith oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20;
Stage #2: methanol in dichloromethane; for 0.0833333 h;
Steps:
General procedure 3: Ester synthesis:
General procedure: To a suspension/solution of carboxylic acid (1.0 eq.) in dry DCM (0.5 M) was added oxalyl chloride (1.1 eq.) and DMF (0.05 eq.) and the mixture was stirred at room temperature until complete gas evolution. Excess MeOH was added and after 5 minutes the solvent was removed under reduced pressure and the product dried in vacuo and used without further purification.
References:
Kl?vekorn, Philip;Pfaffenrot, Bent;Juchum, Michael;Selig, Roland;Albrecht, Wolfgang;Zender, Lars;Laufer, Stefan A. [European Journal of Medicinal Chemistry,2021,vol. 210] Location in patent:supporting information
![2-Chloro-3-nitrobenzoic acid](/CAS/GIF/3970-35-2.gif)
3970-35-2
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![methyl 2-fluoro-3-nitrobenzoate](/CAS/GIF/946126-94-9.gif)
946126-94-9
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$28.00/1g
![METHYL 2-CHLORO-3-NITROBENZOATE](/CAS/GIF/53553-14-3.gif)
53553-14-3
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$14.00/100mg
![methyl 2-fluoro-3-nitrobenzoate](/CAS/GIF/946126-94-9.gif)
946126-94-9
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$28.00/1g
![Methyl chloroformate](/CAS/GIF/79-22-1.gif)
79-22-1
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![1-Fluoro-2-nitrobenzene](/CAS/GIF/1493-27-2.gif)
1493-27-2
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946126-94-9
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$28.00/1g
![METHYL 3-FLUOROBENZOATE](/CAS/GIF/455-68-5.gif)
455-68-5
130 suppliers
$14.00/5g
![methyl 2-fluoro-3-nitrobenzoate](/CAS/GIF/946126-94-9.gif)
946126-94-9
157 suppliers
$28.00/1g