ChemicalBook CAS DataBase List METHYL 2-METHOXY-5-METHYLBENZOATE 97

METHYL 2-METHOXY-5-METHYLBENZOATE 97 synthesis

6synthesis methods

Product Name:METHYL 2-METHOXY-5-METHYLBENZOATE 97
CAS Number:63113-79-1
Molecular formula:C10H12O3
Molecular Weight:180.2

89-56-5
219 suppliers
$11.00/5g

74-88-4
341 suppliers
$15.00/10g

63113-79-1
55 suppliers
$12.00/250mg

Yield:63113-79-1 95%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 0 - 20; for 12 h;

Steps:

47 Methyl 2-methoxy-5-methylbenzoate

Reference example 47 Methyl 2-methoxy-5-methylbenzoate To 5-methylsalicylic acid (3.04 g, 20 mmol) in DMF (100 ml) were added potassium carbonate (8.28 g, 60 mmol) and iodomethane (6.24 g, 44 mmol) under ice cooling and then the mixture was stirred at room temperature for 12 hours. The mixture were extracted by adding 5% sodium hydrogensulfite and ethyl acetate, and the extracted organic layer was washed with 5% citric acid and 5% brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography (hexane-ethyl acetate) to give the captioned compound (3.43 g, 19.1 mmol, yield: 95%) as a colorless oil.

References:

EP1550662,2005,A1 Location in patent:Page/Page column 28

67-56-1 Synthesis