methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate synthesis
1synthesis methods
- Product Name:methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate
- CAS Number:618884-57-4
- Molecular formula:C8H12O3Si
- Molecular Weight:184.26
Yield:618884-57-4 64%
Reaction Conditions:
Stage #1: trimethylsilylacetylenewith n-butyllithium in diethyl ether;hexane at -78; for 0.5 h;Inert atmosphere;
Stage #2: methyl 2-(methoxy(methyl)amino)-2-oxoacetate in diethyl ether;hexane at -78; for 4 h;Inert atmosphere;
References:
Honda, Kazuya;Ohkura, Shun;Hayashi, Yoshihiro;Kawauchi, Susumu;Mikami, Koichi [Chemistry - An Asian Journal,2018,vol. 13,# 19,p. 2842 - 2846] Location in patent:supporting information