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ChemicalBook CAS DataBase List Methyl 3-broMocyclobutane-1-carboxylate

Methyl 3-broMocyclobutane-1-carboxylate synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
2: sodium tetrahydroborate; methanol / 0.5 h / 0 °C / Inert atmosphere
3: carbon tetrabromide; lithium bromide; triphenylphosphine / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

References:

Shindo, Naoya;Ojida, Akio;Tokunaga, Keisuke;Sato, Mami;Kuwata, Keiko;Miura, Chizuru;Fuchida, Hirokazu;Matsunaga, Naoya;Koyanagi, Satoru;Ohdo, Shigehiro [Journal of the American Chemical Society,2020,vol. 142,# 43,p. 18522 - 18531]