![](/CAS/20150408/GIF/35066-32-1.gif)
Methyl 3-cyano-4-Methylbenzoate synthesis
- Product Name:Methyl 3-cyano-4-Methylbenzoate
- CAS Number:35066-32-1
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
Yield:35066-32-1 78%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide at 80; for 5 h;Inert atmosphere;
Steps:
General procedure for thesynthesis of Cyanide 3
General procedure: Iodides 2 (10.0 mmol), zinccyanide (10.0 mmol), tetrakis (triphenylphosphine) palladium (2.0 mmol) weredissolved in 20 mL DMF. The reaction was heated at 80 oC for 5 hoursunder the protection of N2. The mixture was extracted with CH2Cl2 (25×3 mL) andorganic layers were combined, washed with brine, dried over Na2SO4.The solvent was evaporated under vacuum to give crude product, which waspurified by column chromatography on silica gel to give products 3-1~3-3.
References:
Han, Mei;Li, Shan;Ai, Jing;Sheng, Rong;Hu, Yongzhou;Hu, Youhong;Geng, Meiyu [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 23,p. 5679 - 5684] Location in patent:supporting information
![Methyl 3-bromo-4-methylbenzoate](/CAS/GIF/104901-43-1.gif)
104901-43-1
201 suppliers
$6.00/1g
![Methyl 3-cyano-4-Methylbenzoate](/CAS/20150408/GIF/35066-32-1.gif)
35066-32-1
41 suppliers
inquiry
![Methyl 4-(bromomethyl)benzoate](/CAS/GIF/2417-72-3.gif)
2417-72-3
373 suppliers
$7.00/5g
![Tosyl cyanide](/CAS/GIF/19158-51-1.gif)
19158-51-1
167 suppliers
$52.00/1 g
![Methyl 3-cyano-4-Methylbenzoate](/CAS/20150408/GIF/35066-32-1.gif)
35066-32-1
41 suppliers
inquiry
![3-Bromo-4-methylbenzoic acid](/CAS/GIF/7697-26-9.gif)
7697-26-9
265 suppliers
$6.00/5g
![Methyl 3-cyano-4-Methylbenzoate](/CAS/20150408/GIF/35066-32-1.gif)
35066-32-1
41 suppliers
inquiry
![4-Methyl-3-nitrobenzoic acid](/CAS/GIF/96-98-0.gif)
96-98-0
352 suppliers
$8.00/10g
![Methyl 3-cyano-4-Methylbenzoate](/CAS/20150408/GIF/35066-32-1.gif)
35066-32-1
41 suppliers
inquiry