ChemicalBook CAS DataBase List Methyl 3-methyl-4-nitrobenzoate

Methyl 3-methyl-4-nitrobenzoate synthesis

9synthesis methods

Product Name:Methyl 3-methyl-4-nitrobenzoate
CAS Number:24078-21-5
Molecular formula:C9H9NO4
Molecular Weight:195.17

67-56-1 Synthesis

67-56-1
757 suppliers
$7.29/5ml-f

3113-71-1 Synthesis

3113-71-1
473 suppliers
$6.00/25g

24078-21-5
244 suppliers
$6.00/5g

Yield:24078-21-5 96%

Reaction Conditions:

with thionyl chloride at 0 - 80; for 1 h;

Steps:

40.1
Step 1. Methyl 3-methyl-4-nitrobenzoate To a solution of 3-methyl-4-nitrobenzoic acid (30 g, 165.61 mmol) in methanol (300 mL), was added thionyl chloride (25 mL) dropwise with stirring at 0° C. After stirring for 1 h at 80° C., the resulting mixture was concentrated under vacuum to give residue, which was dissolved in petroleum ether (100 mL) and filtrated to give methyl 3-methyl-4-nitrobenzoate as a white solid (31 g, 96%). LC/MS (ES, m/z): [M+H]⁺ 196.0 ¹H-NMR (300 MHz, CD₃Cl) δ 7.99-8.04 (m, 3H), 3.98 (s, 3H), 2.64 (s, 3H)

References:

BIOENERGENIX US2012/277224, 2012, A1 Location in patent:Page/Page column 33

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