Methyl 3-methyl-4-nitrobenzoate synthesis
- Product Name:Methyl 3-methyl-4-nitrobenzoate
- CAS Number:24078-21-5
- Molecular formula:C9H9NO4
- Molecular Weight:195.17
67-56-1
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$7.29/5ml-f
3113-71-1
480 suppliers
$6.00/25g
24078-21-5
245 suppliers
$6.00/5g
Yield:24078-21-5 96%
Reaction Conditions:
with thionyl chloride at 0 - 80; for 1 h;
Steps:
40.1
Step 1. Methyl 3-methyl-4-nitrobenzoate To a solution of 3-methyl-4-nitrobenzoic acid (30 g, 165.61 mmol) in methanol (300 mL), was added thionyl chloride (25 mL) dropwise with stirring at 0° C. After stirring for 1 h at 80° C., the resulting mixture was concentrated under vacuum to give residue, which was dissolved in petroleum ether (100 mL) and filtrated to give methyl 3-methyl-4-nitrobenzoate as a white solid (31 g, 96%). LC/MS (ES, m/z): [M+H]+ 196.0 1H-NMR (300 MHz, CD3Cl) δ 7.99-8.04 (m, 3H), 3.98 (s, 3H), 2.64 (s, 3H)
References:
BIOENERGENIX US2012/277224, 2012, A1 Location in patent:Page/Page column 33
80866-75-7
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865-33-8
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$12.50/100G
24078-21-5
245 suppliers
$6.00/5g
3113-71-1
480 suppliers
$6.00/25g
24078-21-5
245 suppliers
$6.00/5g
3240-34-4
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$7.00/10g
3113-71-1
480 suppliers
$6.00/25g
24078-21-5
245 suppliers
$6.00/5g