ChemicalBook CAS DataBase List METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE

METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE synthesis

2synthesis methods

Product Name:METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE
CAS Number:202146-16-5
Molecular formula:C9H10ClNO2
Molecular Weight:199.63

18595-14-7 Synthesis

18595-14-7
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METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE

202146-16-5
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$45.00/25mg

Yield:202146-16-5 82%

Reaction Conditions:

with N-chloro-succinimide in dichloromethane at 20;

Steps:

3 Methyl 4-amino-3-chloro-5-methylbenzoate

Methyl 4-amino-3-methyl benzoate (5.0 g, 30.3 mmol) and dry dichloromethane (50 mL) were added in a threeneckedflask and stirred. N-chlorosuccinimide (4.85 g, 36.3 mmol) was added and the mixture was allowed to reactovernight at room temperature. The reaction mixture was poured into water (100 mL), extracted three times with dichloromethane.The organic phase was combined, dried with anhydrous sodium sulfate, filtered, concentrated to dry, andpurified by column to obtain the target compound (5.1 g, 82%) as a white solid.1H NMR (400 MHz, CDCl3): δ 7.85 (s, 1H), 7.67 (s, 1H), 4.33 (brs, 2H), 3.86 (s, 3H), 2.22 (s, 3H).

References:

EP3831824,2021,A1 Location in patent:Paragraph 0093-0095

Benzoic acid, 4-amino-3-chloro-5-[(methylthio)methyl]-, methyl ester

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202146-16-5
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References

METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE Related Search:

Methyl 4-amino-3-(trifluoromethoxy)benzoate METHYL 4-AMINO-3-CHLOROBENZOATE Methyl-4-amino-3-fluorobenzoate Methyl 4-amino-2-chlorobenzoate Methyl 4-amino-2-methoxybenzoate METHYL 4-AMINO-3,5-DICHLOROBENZOATE methyl 4-amino-2-chloro-5-iodobenzoate Methyl-4-amino-3-bromo-5-methylbenzoate Methyl 4-amino-3-methoxybenzoate Methyl 4-amino-3-hydroxybenzoate