ChemicalBook CAS DataBase List Methyl 4-amino-3-methoxybenzoate

Methyl 4-amino-3-methoxybenzoate synthesis

8synthesis methods

Product Name:Methyl 4-amino-3-methoxybenzoate
CAS Number:41608-64-4
Molecular formula:C9H11NO3
Molecular Weight:181.19

67-56-1 Synthesis

67-56-1
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2486-69-3 Synthesis

2486-69-3
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41608-64-4
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Yield:41608-64-4 100%

Reaction Conditions:

Stage #1:methanol;3-methoxy-4-aminobenzoic acid;sulfuric acid at 70; for 24 h;
Stage #2: with sodium hydroxide in water; pH=8

Steps:

BA-20
A solution of 4-amino-3-methoxybenzoic acid (1.5 g, 8.97 mmole) in 15 ml methanol and 4.8 ml sulfuric acid 95-98% was heated at 70° C. for 24 hrs. Upon completion, the mixture was concentrated down and basified with 2N NaOH solution to pH=8. A solid precipitated out. The suspension was filtered off, solid was washed with water, dried to afford 1.62 g tan solid (56), 100% yield. ¹H-NMR (400 MHz, DMSO)

References:

DECODE GENETICS EHF US2009/130076, 2009, A1 Location in patent:Page/Page column 31; 32

FullText

5081-37-8 Synthesis