ChemicalBook CAS DataBase List Methyl 4-bromothiophene-2-carboxylate

Methyl 4-bromothiophene-2-carboxylate synthesis

7synthesis methods

Product Name:Methyl 4-bromothiophene-2-carboxylate
CAS Number:62224-16-2
Molecular formula:C6H5BrO2S
Molecular Weight:221.07

16694-18-1
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$6.00/1g

62224-16-2
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$13.00/1g

Yield:62224-16-2 98%

Reaction Conditions:

with sulfuric acid in methanol at 65; for 17 h;

Steps:

18.1
A few drops of concentrated sulphuric acid are added to a solution of 5.0 g of the compound obtained during Stage 1 of Preparation 1 in 25 ml of methanol. The reaction medium is stirred at 65° C. for 17 hours and is then concentrated under reduced pressure. The oily residue obtained is dissolved in ethyl acetate (200 ml), washed with water (3×100 ml), dried over sodium sulphate and then concentrated under reduced pressure in order to produce 5.24 g of the desired product. Yield: 98% 1H NMR (CDCl3) δ (ppm): 3.90 (s, 3H), 7.45 (s, 1H), 7.70 (s, 1H)

References:

Dublanchet, Anne-Claude;Compere, Delphine;Cluzeau, Philippe;Blais, Stephane;Denis, Alexis;Ducrot, Pierre;Courte, Karine;Descamps, Sophie US2004/72871, 2004, A1 Location in patent:Page/Page column 29

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67-56-1 Synthesis