ChemicalBook CAS DataBase List METHYL 4-DIETHYLAMINOBENZOATE

METHYL 4-DIETHYLAMINOBENZOATE synthesis

5synthesis methods

Product Name:METHYL 4-DIETHYLAMINOBENZOATE
CAS Number:91563-80-3
Molecular formula:C12H17NO2
Molecular Weight:207.27

67-56-1 Synthesis

67-56-1
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5429-28-7 Synthesis

5429-28-7
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91563-80-3
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Yield:91563-80-3 65%

Reaction Conditions:

with thionyl chloride for 5 h;Reagent/catalyst;

Steps:

Esterification of p-Aminobenzoic Acida) With Thionyl Chloride and Methanol24

General procedure: To a solution of the benzoic acid derivative (10 mmol) in anhydrous methanol (35 mL)was added dropwise thionyl chloride (1.1 mL, 15 mmol) under vigorous stirring (stirbar). After 5 h, about 25 mL of the methanol was distilled off and the residue was pouredonto 50 mL of ice water. Then saturated aqueous sodium bicarbonate was added withstirring until the evolution of carbon dioxide ceased. The resulting precipitate wascollected and recrystallized from methanol.

References:

Pietrzak, Marek;J?drzejewska, Beata;M?drzejewska, Dorota;Bajorek, Agnieszka [Organic Preparations and Procedures International,2017,vol. 49,# 1,p. 45 - 52]

75-05-8 Synthesis