ChemicalBook CAS DataBase List Methyl 5-Acetylthiophene-2-carboxylate

Methyl 5-Acetylthiophene-2-carboxylate synthesis

4synthesis methods

Product Name:Methyl 5-Acetylthiophene-2-carboxylate
CAS Number:4101-81-9
Molecular formula:C8H8O3S
Molecular Weight:184.21

4066-41-5 Synthesis

4066-41-5
211 suppliers
$6.00/1g

18107-18-1
210 suppliers
$33.00/5g

4101-81-9
33 suppliers
$129.00/1g

Yield:4101-81-9 100%

Reaction Conditions:

in methanol;toluene at 0 - 20;

Steps:

20.1

Step 1: methyl 5-acetylthiophene-2-carboxylateTo a solution of 5-acetylthiophene-2-carboxylic acid (3.24 g, 19.0 mmol) dissolved in a mixture of toluene (50 mL) and methanol (50 mL) cooled to 0° C. was added 2.0 M trimethylsilyldiazomethane in ether (19.0 mL, 38.1 mmol) dropwise. Upon complete addition, the reaction mixture was allowed to warm to room temperature overnight. The reaction was quenched with the addition of acetic acid and the solvent was removed. The residue thus obtained was partitioned between ethyl acetate and saturated aqueous NaHCO₃and upon separation, the organic layer was dried over anhydrous magnesium sulfate and concentrated to afford the desired product (3.49 g, 100%). LC-MS: (FA) ES+ 185)

References:

US2011/213003,2011,A1 Location in patent:Page/Page column 64

4066-41-5 Synthesis

4066-41-5
211 suppliers
$6.00/1g