![](/CAS/GIF/73505-48-3.gif)
METHYL-5-METHOXY-2-METHYLBENZOATE synthesis
- Product Name:METHYL-5-METHOXY-2-METHYLBENZOATE
- CAS Number:73505-48-3
- Molecular formula:C9H10O3
- Molecular Weight:166.17
![2-Methylfuran](/CAS/20180808/GIF/534-22-5.gif)
534-22-5
291 suppliers
$10.00/5mL
![Methyl propiolate](/CAS/GIF/922-67-8.gif)
922-67-8
342 suppliers
$6.00/1g
![METHYL-5-METHOXY-2-METHYLBENZOATE](/CAS/GIF/73505-48-3.gif)
73505-48-3
111 suppliers
$57.00/1g
Yield:73505-48-3 79%
Reaction Conditions:
with yttrium(III) trifluoromethanesulfonate in toluene at 150; for 3 h;Sealed tube;Reagent/catalyst;Solvent;
Steps:
3 Example 3 Synthesis of methyl 5-hydroxy-2-methylbenzoate
Example 3 Synthesis of methyl 5-hydroxy-2-methylbenzoate Toluene k_Jk A reactor was charged with yttrium triflate (48 mg), and then toluene(0.3 ml) and methyl propiolate (151 mg, 160 μΚ) were added. The reactor was sealed, heated to 150 °C with stirring. 2-Methylfuran (157 mg, 172 μΚ) was added continuously over a 3 hour period. The reaction mixture was cooled to room temperature and water (10 ml) was added. The organics were separated and the aqueous phase was extracted with toluene (2 x 10 ml). The combined organics were washed with water (10 ml), dried (Na2S04) and filtered. The organic solution was reduced by rotary evaporation to yield an oil, which was purified on a Reveleris X2 Flash Chromatography System, eluting with n-hexane and ethyl acetate.Appropriate fractions were collected for the product peak and were reduced by rotary evaporation to obtain the desired product as a light brown solid (354 mg, 79%). The structure was confirmed as methyl 5-hydroxy-2-methylbenzoate by 1H NMR.
References:
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO;CROCKATT, Marc;URBANUS, Jan Harm;KONST, Paul Mathijs;DE KONING, Martijn Constantijn WO2016/114668, 2016, A1 Location in patent:Page/Page column 23
![5-AMINO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/18595-12-5.gif)
18595-12-5
115 suppliers
$10.00/1g
![METHYL-5-METHOXY-2-METHYLBENZOATE](/CAS/GIF/73505-48-3.gif)
73505-48-3
111 suppliers
$57.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
740 suppliers
$7.29/5ml-f
![5-HYDROXY-2-METHYL-BENZOIC ACID](/CAS/GIF/578-22-3.gif)
578-22-3
205 suppliers
$8.00/1g
![METHYL-5-METHOXY-2-METHYLBENZOATE](/CAS/GIF/73505-48-3.gif)
73505-48-3
111 suppliers
$57.00/1g
![5-HYDROXY-2-METHYL-BENZOIC ACID](/CAS/GIF/578-22-3.gif)
578-22-3
205 suppliers
$8.00/1g
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
562 suppliers
$17.92/100G
![METHYL-5-METHOXY-2-METHYLBENZOATE](/CAS/GIF/73505-48-3.gif)
73505-48-3
111 suppliers
$57.00/1g
![5-HYDROXY-2-METHYL-BENZOIC ACID](/CAS/GIF/578-22-3.gif)
578-22-3
205 suppliers
$8.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
208 suppliers
$33.00/5g
![METHYL-5-METHOXY-2-METHYLBENZOATE](/CAS/GIF/73505-48-3.gif)
73505-48-3
111 suppliers
$57.00/1g