Methyl 6-broMo-1-Methylindole-2-carboxylate, 97% synthesis
- Product Name:Methyl 6-broMo-1-Methylindole-2-carboxylate, 97%
- CAS Number:680569-18-0
- Molecular formula:C11H10BrNO2
- Molecular Weight:268.11
16732-65-3
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680569-18-0
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Yield:680569-18-0 256.5 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20 - 60; for 49 h;
Steps:
57.1
MeI (0.58 mL, 9.32 mmol) was added to a mixture of 6-bromo-1H-indole-2-carboxylic acid (1.00 g, 4.16 mmol) and K2CO3(1.48 g, 10.7 mmol) in DMF 14 mL at rt. After the reaction mixture was stirred at rt for 1 hour, it was stirred at 60 °C for 24 hours. Then another portion of MeI (0.59 mL, 9.48 mmol) was added to the reaction mixture at rt. The resulting mixture was stirred at 60 °C for 24 hours before water was poured to this reaction at rt. The resulting solid was filtered and washed with water. The pink solid was purified by column chromatography (silica gel, gradient elution, 0 to 20% EtOAc/hexanes) to provide methyl 6-bromo-1-methyl-1H-indole-2-carboxylate (256.5 mg). LCMS Method C, RT = 5.296 min, m/z = 268.0 [M+H]+, exact mass: 266.9895.
References:
WO2022/147302,2022,A1 Location in patent:Paragraph 01097
16732-65-3
216 suppliers
$11.00/1g
616-38-6
660 suppliers
$5.00/5G
680569-18-0
32 suppliers
$24.89/250mg