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401792-82-3

methyl 6-methoxy-5-methylpicolinate synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: SeO2 / pyridine / 26 h / Heating
2.1: 8.2 g / conc. H2SO4 / 8 h / Heating
3.1: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C
4.1: Ac2O / 3 h / Heating
4.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C
5.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C

References:

Adamczyk, Maciej;Akireddy, Srinivasa Rao;Reddy, Rajarathnam E [Tetrahedron,2002,vol. 58,# 34,p. 6951 - 6963]