![](/CAS/GIF/136117-69-6.gif)
METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE synthesis
- Product Name:METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
- CAS Number:136117-69-6
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
![IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID](/CAS/GIF/139022-25-6.gif)
139022-25-6
161 suppliers
$10.00/250mg
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
342 suppliers
$15.00/10g
![METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE](/CAS/GIF/136117-69-6.gif)
136117-69-6
117 suppliers
$32.00/500mg
Yield: 39%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide
Steps:
62.B B.
B. Imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester Cesium carbonate (15.7 g, 48.2 mmol) and iodomethane (1.50 ml, 24.2 mmol) were added to a solution of imidazo[1,2-a]pyridine-6-carboxylic acid (2.61 g, 16.1 mmol) in DMF (100 ml). The reaction was stirred at ambient temperature overnight, then poured into brine (100 ml) and extracted with ethyl acetate (3*100 mL). The combined organics were washed with saturated sodium bicarbonate solution (25 mL), and a 1N HCl solution (25 mL) then dried over MgSO4 and evaporated to give imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester as a yellow solid (1.1 g, 39%). 1H NMR (250 MHz, CDCl3): δ 8.96 (s, 1H), 7.8-7.6 (m, 4H), 3.98 (s, 3H). MS [EI+] 177 (M+H)+.
References:
Gardinier, Kevin M.;Gernert, Douglas J.;Grese, Timothy A.;Neel, David A.;Mapes, Christopher M.;Michellys, Pierre-Yves;Boehm, Marcus F. US2004/167160, 2004, A1
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$5.00/5g
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36052-24-1
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$10.00/1g
![METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE](/CAS/GIF/136117-69-6.gif)
136117-69-6
117 suppliers
$32.00/500mg
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![Methyl 6-aminonicotinate](/CAS/GIF/36052-24-1.gif)
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$10.00/1g
![METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE](/CAS/GIF/136117-69-6.gif)
136117-69-6
117 suppliers
$32.00/500mg
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67-56-1
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$7.29/5ml-f
![IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID](/CAS/GIF/139022-25-6.gif)
139022-25-6
161 suppliers
$10.00/250mg
![METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE](/CAS/GIF/136117-69-6.gif)
136117-69-6
117 suppliers
$32.00/500mg
![Methyl 6-aminonicotinate](/CAS/GIF/36052-24-1.gif)
36052-24-1
253 suppliers
$10.00/1g
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17157-48-1
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![METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE](/CAS/GIF/136117-69-6.gif)
136117-69-6
117 suppliers
$32.00/500mg