milenperone synthesis
- Product Name:milenperone
- CAS Number:59831-64-0
- Molecular formula:C22H23ClFN3O2
- Molecular Weight:415.894
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![2H-Benzimidazol-2-one, 5-chloro-1,3-dihydro-1-[3-[(methylsulfonyl)oxy]propyl]-](/CAS/20210305/GIF/62780-79-4.gif)
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59831-64-0
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Yield:59831-64-0 0.6 parts (10%)
Reaction Conditions:
with sodium carbonate
Steps:
XXXII Example XXXII
Example XXXII A mixture of 5.5 parts of 3-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl methanesulfonate, 3.6 parts of (4-fluorophenyl) (4-piperidinyl) methanone, 6 parts of sodium carbonate and 80 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. After cooling, the reaction mixtue is filtered and the filtrate is evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and recrystallized from 4-methyl-2-pentanone, yielding 0.6 parts (10%) of 5-chloro-1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl] propyl} -1,3-dihydro-2H-benzimidazol-2-one; mp. 163.7° C.
References:
US4035369,1977,A