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ChemicalBook CAS DataBase List ML337

ML337 synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine / N,N-dimethyl-formamide / 1.08 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 4 h / 20 °C

References:

Wenthur, Cody J.;Morrison, Ryan;Felts, Andrew S.;Smith, Katrina A.;Engers, Julie L.;Byers, Frank W.;Daniels, J. Scott;Emmitte, Kyle A.;Conn, P. Jeffrey;Lindsley, Craig W. [Journal of Medicinal Chemistry,2013,vol. 56,# 12,p. 5208 - 5212]

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