N-(2-Hydroxybenzyl)-4-nitroaniline synthesis

4synthesis methods

Product Name:N-(2-Hydroxybenzyl)-4-nitroaniline
CAS Number:13159-73-4
Molecular formula:C13H12N2O3
Molecular Weight:244.25

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Yield:13159-73-4 97%

Reaction Conditions:

with nickel(II) oxide;ammonium formate;sodium hydroxide in ethanol;water at 45; pH=8; for 4 h;

Steps:

Catalytic activity of NiO NPs on the reduction of aromatic imines

General procedure: Imine 1a (30 mg, 0.14 mmol), biosynthesized NiO nanoparticles(1 mg) and ammonium formate (0.13 mmol), ethanol(2 ml) were mixed and stirred in a magnetic stirrer. NaOH(0.05 mmol) in 2ml of water was added to the reaction mixtureto maintain the pH at 8 and heated to about 45 C. Completion of the reaction was confirmed by checking TLC.Then, the catalyst was removed through centrifugation and the organic layer was evaporated. The crude product was extracted with ethyl acetate and dried using anhydrous sodium sulfate. All the products were purified using column chromatography.

References:

Muthuvinothini, Alagesan;Stella, Selvaraj [Inorganic and Nano-Metal Chemistry,2021,vol. 51,# 2,p. 267 - 271]

90-02-8 Synthesis