N-(4-AMINOPHENYL)-2-CHLOROBENZAMIDE synthesis
- Product Name:N-(4-AMINOPHENYL)-2-CHLOROBENZAMIDE
- CAS Number:27831-89-6
- Molecular formula:C13H11ClN2O
- Molecular Weight:246.69
55501-45-6
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$28.60/250mg
27831-89-6
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$199.00/500mg
Yield:27831-89-6 44%
Reaction Conditions:
with iron(III) chloride;pyrographite;hydrazine hydrate in ethanol at 85; for 2 h;
Steps:
1.2. General procedure for the preparation of the N-(4-aminophenyl)-2-methylbenzamide derivatives 13a-u
General procedure: A mixture of 12a-u (3.8 mmol) in ethanol (40 mL) was heated to 60 oC. FeCl3 (0.1 g) and activated charcoal (0.5 g) were added, and the mixture was heated to 85 oC. Hydrazine hydrate (8 mmol, 4 mL) was added dropwise, and the reaction was stirred for 2 h. Upon completion, the mixture was filtered, washed with ethanol, and concentrated in vacuo to afford compounds 13a-u.
References:
Wang, Ru;Liu, Hu;You, Yuan-Yuan;Wang, Xin-Yu;Lv, Bing-Bing;Cao, Li-Qin;Xue, Jia-Yu;Xu, Yun-Gen;Shi, Lei [Bioorganic and Medicinal Chemistry Letters,2021,vol. 36,art. no. 127788] Location in patent:supporting information
100-01-6
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27831-89-6
14 suppliers
$199.00/500mg
71026-66-9
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$10.00/1g
27831-89-6
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$199.00/500mg
118-91-2
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$14.00/25g
27831-89-6
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$199.00/500mg
609-65-4
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$21.00/25g
27831-89-6
14 suppliers
$199.00/500mg