ChemicalBook CAS DataBase List N-(4-Nitrophenyl)pyridin-2-amine

N-(4-Nitrophenyl)pyridin-2-amine synthesis

9synthesis methods

Product Name:N-(4-Nitrophenyl)pyridin-2-amine
CAS Number:24068-29-9
Molecular formula:C11H9N3O2
Molecular Weight:215.21

504-29-0
541 suppliers
$5.00/5G

586-78-7
9 suppliers
$14.00/5g

24068-29-9
14 suppliers
$184.00/250mg

Yield:24068-29-9 76%

Reaction Conditions:

with potassium tert-butylate in dimethylsulfoxide-d6 at 60; for 5 h;

Steps:

Synthesis of compounds (1a-l); general procedure

General procedure: A mixture of the appropriate N-nucleophile (2 mmol), 4-bromonitrobenzene(2 mmol), t-ButOK or KOH (in the case of 1g, 1h)(2.2 mmol) in dimethyl sulfoxide (2.5 mL) was stirred at 60 °C for 5 h(8 h in the case of 1b). After cooling and addition of water (60 mL),either a solid precipitated which was filtered, washed with water andrecrystallised from an appropriate solvent to give the product, or asuspension was generated which was extracted with ethyl acetate(3 × 30 mL), dried over Na2SO4, concentrated under reduced pressureand recrystallised from an appropriate solvent to give the desiredproduct

References:

Ghasemi, Zarrin;Shahrak, Nasim Shahi;Roomi, Behzad Jalali;Zakeri, Ziba [Journal of Chemical Research,2015,vol. 39,# 2,p. 73 - 75]

5255-67-4 Synthesis