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N-ACETYL-DL-ALLYLGLYCINE synthesis

5synthesis methods
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Yield:50299-14-4 82%

Reaction Conditions:

Stage #1: ethyl 2-acetamido-2-(ethoxycarbonyl)-4-pentenoatewith water;potassium hydroxide at 100; for 3 h;
Stage #2: with hydrogenchloride at 100; pH=3.5; for 3 h;

References:

Gharakhanian, Eric G.;Bahrun, Ehab;Deming, Timothy J. [Journal of the American Chemical Society,2019,vol. 141,# 37,p. 14530 - 14533] Location in patent:supporting information

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