N-BOC-N-Methyl-3-broMoaniline synthesis
- Product Name:N-BOC-N-Methyl-3-broMoaniline
- CAS Number:57598-34-2
- Molecular formula:C12H16BrNO2
- Molecular Weight:286.16
25216-74-4
53 suppliers
$17.00/1g
74-88-4
341 suppliers
$15.00/10g
57598-34-2
16 suppliers
$320.00/5g
Yield:57598-34-2 100%
Reaction Conditions:
Stage #1: (3-bromo-phenyl)-carbamic acid t-butyl esterwith sodium hydride in DMF (N,N-dimethyl-formamide);
Stage #2: iodomethane in DMF (N,N-dimethyl-formamide) at 20; for 5 h;
Steps:
20.c.2 c. 2: tert-butyl (3-Bromophenyl) methylcarbamate
7.6 g (190 mmol) of 60% sodium hydride are added portionwise to a solution of 47 g (173 mmol) of tert-butyl (3-bromophenyl) methylcarbamate in 500 ml of dimethylformamide. After the evolution of gas has ceased, 54 ml (865 mmol) of methyl iodide are added and the reaction medium is stirred at room temperature for 5 hours. After addition of water, the medium is extracted with ethyl acetate. The ethyl acetate phase is washed thoroughly with water, dried over magnesium sulfate, filtered and evaporated. 49 g (100%) of tert- butyl (3-bromophenyl) methylcarbamate are obtained.
References:
WO2004/113331,2004,A1 Location in patent:Page 91
24424-99-5
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$13.50/25G
66584-32-5
86 suppliers
$35.00/1g
57598-34-2
16 suppliers
$320.00/5g
24424-99-5
822 suppliers
$13.50/25G
57598-34-2
16 suppliers
$320.00/5g
591-19-5
318 suppliers
$10.00/10g
57598-34-2
16 suppliers
$320.00/5g