![](/CAS/GIF/194163-91-2.gif)
N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER synthesis
- Product Name:N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER
- CAS Number:194163-91-2
- Molecular formula:C12H18N2O4
- Molecular Weight:254.28
![(2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER](/CAS/GIF/84520-67-2.gif)
84520-67-2
58 suppliers
$14.00/250mg
![N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER](/CAS/GIF/194163-91-2.gif)
194163-91-2
41 suppliers
$323.00/250mg
Yield:194163-91-2 205 mg (11%)
Reaction Conditions:
in dimethyl sulfoxide;
Steps:
B Step B
Step B (4R)-1-(tert-Butyloxycarbonyl)-4-cyano-L-Proline Methyl Ester A mixture of (4R)-1-(tert-butyloxycarbonyl)-4-(methane-sulfonyloxy)-L-proline methyl ester (2.31 g, 7.14 mmol) and sodium cyanide (3.5 g, 71.4 mmol) in dry dimethylsulfoxide (46 mL) was stirred for 24 hours at 55° C. under a nitrogen atmosphere. The cooled reaction mixture was diluted with ethyl acetate, washed with water (2*), saturated brine solution, dried (MgSO4), and evaporated. The crude product mixture was subjected to flash silica gel chromatography eluding with 15% acetone/hexane. Fractions containing the desired nitrile were combined and evaporated to afford a colorless oil; yield 205 mg (11%).
References:
US5821261,1998,A
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773837-37-9
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107 suppliers
$17.00/1g
![N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER](/CAS/GIF/194163-91-2.gif)
194163-91-2
41 suppliers
$323.00/250mg
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151-50-8
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$43.36/100g
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121147-93-1
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![N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER](/CAS/GIF/194163-91-2.gif)
194163-91-2
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$323.00/250mg
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13726-69-7
430 suppliers
$5.00/1g
![N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER](/CAS/GIF/194163-91-2.gif)
194163-91-2
41 suppliers
$323.00/250mg
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834 suppliers
$6.00/5g
![N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER](/CAS/GIF/194163-91-2.gif)
194163-91-2
41 suppliers
$323.00/250mg