N'-Hydroxycyclopropanecarboximidamide synthesis

Yield:51285-13-3 80%

Reaction Conditions:

with hydroxylamine;potassium carbonate in ethanol;water at 20; for 18 h;

Steps:

N-hydroxy-cyclopropanecarboxamidine

6.00 g (43.41 mmol) potassium carbonate are dissolved in 19 ml of water, 60 ml of ethanol, 3.00 g (43.17 mmol) hydroxylamine and 3.25 ml (43.25 mmol) cyclopropylcyamide are added. The reaction mixture is stirred for 18 hours at ambient temperature, then evaporated down and re-evaporated with toluene. The residue is mixed with ethanol, suction filtered and the filtrate is evaporated to dryness. Yield: 3.47 g (80% of theoretical)

References:

US2007/238730,2007,A1 Location in patent:Page/Page column 24