N,N,4-TRIMETHYL-2-PYRIDINAMINE synthesis

4synthesis methods

Product Name:N,N,4-TRIMETHYL-2-PYRIDINAMINE
CAS Number:20173-72-2
Molecular formula:C8H12N2
Molecular Weight:136.19

695-34-1
526 suppliers
$5.00/10g

64-19-7 Synthesis

64-19-7
1535 suppliers
$10.00/25ML

20173-72-2
17 suppliers
$45.00/50mg

Yield:20173-72-2 88%

Reaction Conditions:

with formaldehyd;sodium cyanoborohydride in water;acetonitrile at 0 - 20; for 168 h;

Steps:

1.1A

EXAMPLE 1; SYNTHESIS OF REAGENT [5-(7-CHLORO-2,5-DIMETHYL-PYRAZOLO[1,5-A]PYRIMΓDIN-3-YL)-4-METHYL-PYRIDIN-2- YL] -DIMETHYL- AMINE; EPO ; Step IA; To a mixture of 2-amino-4-picoline (33 g), NaBH₃CN (57 g), formaldehyde (37% aq. solution, 240 mL) in acetonitrile (1 L) and water (200 mL) was added dropwise acetic acid (60 mL) at 0 °C in 2 hr. The resultant solution was stirred at RT for 7 days and then concentrated in vacuo. The residue was basified with solid NaOH to pH 10 and extracted with hexanes (3x 700 mL). The combined extract was washed with IN aq. NaOH and brine, dried over Na₂SO₄ and evaporated in vacuo to give 2-dimethylamino-4- methylpyridine as a colorless oil (Cmpd Ia, 36 g, 88%). ¹H NMR (CDCl₃): 2.26 (s, 3H), 3.07 (s, 6H), 6.33 (s, IH), 6.40 (d, IH), 8.02 (d, IH); MS (CI) m/e 137 (MH⁺).

References:

WO2006/44958,2006,A1 Location in patent:Page/Page column 38-39

695-34-1
526 suppliers
$5.00/10g

74-88-4
340 suppliers
$15.00/10g

20173-72-2
17 suppliers
$45.00/50mg

References

695-34-1
526 suppliers
$5.00/10g

50-00-0 Synthesis

50-00-0
843 suppliers
$10.00/25g

20173-72-2
17 suppliers
$45.00/50mg

References

695-34-1
526 suppliers
$5.00/10g

20173-72-2
17 suppliers
$45.00/50mg

References