N,N-Di-n-propyl-3-MethylbenzaMide, 97% synthesis
1synthesis methods
- Product Name:N,N-Di-n-propyl-3-MethylbenzaMide, 97%
- CAS Number:5448-35-1
- Molecular formula:C14H21NO
- Molecular Weight:219.32
Yield:5448-35-1 86%
Reaction Conditions:
Stage #1: di-n-propylaminewith ethylmagnesium bromide in tetrahydrofuran;diethyl ether at 30; for 1 h;
Stage #2: 3-Methylbenzonitrilewith ethylmagnesium bromide in tetrahydrofuran;diethyl ether at 30; for 1 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;diethyl ether;dichloromethane at 22;
References:
Bhattacharya, Apurba;Plata, Robert Erik;Villarreal, Victor;Muramulla, Savitha;Wu, Jiejun [Tetrahedron Letters,2006,vol. 47,# 4,p. 505 - 506]